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Methotrexate-loaded nanoparticle DNA scavengers (cNP-pp-PEG) have been developed to directly reach the core of inflammation, which not only mitigate systemic toxicity possibly induced by the strong positive charge of cationic nanoparticles (cNPs) during intravenous circulation but also enhance the therapeutic effect of cNPs (93)

10.1111/j.1749-6632.1995.tb17369.x 75 LanderosR

Following the aggregation of FcRI IgEallergen complexes and the activation of Src family kinases (such as Fyn, Lyn, and Syk), downstream signaling molecules (such as LAT and SLP-76) are phosphorylated and activated